![]() These results suggest that oxycodone and hydrocodone have similarly potent analgesic effects in the first hour of treatment for ED patients with acute fractures. Adverse effect profiles were similar, with the exception of a higher incidence of subsequent constipation with the use of hydrocodone. Treatment with acetaminophen and either oxycodone, 5 mg po, or hydrocodone, 5 mg po, resulted in pain relief among ED patients with acute fractures, and there was no difference between the two agents at 30 and 60 minutes. ![]() There was no difference between the groups in nausea, vomiting, itching, or drowsiness however, the hydrocodone patients had a higher incidence of constipation (oxycodone 0%, hydrocodone 21%, difference in proportions 21%, 95% CI = 3% to 39% more with hydrocodone). There was no difference in pain between the patients treated with oxycodone and hydrocodone at 30 minutes (mean difference between groups -0.6, 95% CI = -1.8 to 0.5) or at 60 minutes (mean difference -0.5, 95% CI = -2.0 to 1.0). Patients in both groups had pain relief from baseline to 30 minutes (oxycodone mean change 3.7, 95% CI = 2.9 to 4.6 hydrocodone mean change 2.5, 95% CI = 1.7 to 3.3), and from baseline to 60 minutes (oxycodone mean change 4.4, 95% CI = 3.2 to 5.6 hydrocodone mean change 3.0, 95% CI = 2.1 to 3.9). There was no difference between the two groups in age, weight, gender, ethnicity, diagnoses, baseline pain scores, or vital signs. Sixty-seven subjects completed the ED study period (n = 35, oxycodone n = 32, hydrocodone). Seventy-three subjects were randomized to receive oxycodone or hydrocodone. Ninety-five-percent confidence intervals (95% CIs) constructed about means and proportions were used to assess differences between the oxycodone and hydrocodone groups in analgesic efficacy and side effects. Measurements included demographic information pain scores on a verbal numeric rating scale at baseline and at 30 and 60 minutes vital signs at baseline and at 30 and 60 minutes and adverse effects. Subjects were randomized to receive either oxycodone (5 mg orally ) with acetaminophen, or hydrocodone (5 mg po) with acetaminophen. Eligible participants included ED patients over the age of 12 years with fractures who consented to participate. This prospective, double-blind, randomized, controlled trial was conducted at an urban trauma center with an annual census of 65,000. To compare the efficacies of oxycodone and hydrocodone for the treatment of acute pain associated with fractures in emergency department (ED) patients. ![]() However, to the best of the authors' knowledge, no previous reports have compared the efficacies of these commonly prescribed agents. ChildrenUse and dose must be determined by your doctor. Generic: Dose depends on the strength of the tablet and must be determined by your doctor. However, the dose is usually not more than 8 tablets per day. Your doctor may increase your dose as needed. Previous studies have demonstrated the efficacy of oxycodone and hydrocodone for the treatment of acute pain. Norco 5/325: 1 or 2 tablets every 4 to 6 hours as needed. ![]()
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